The purpose of this case study is to investigate the post-operative outcomes of acellular dermal regenerative tissue matrix and allogeneic decellularized particular human placental connective tissue matrix as augmentation grafts during open Achilles tendon repair. In this case, a 47-year-old diabetic African American male presented to clinic eleven days status post near complete rupture of the Achilles tendon, proximal to the insertion on the calcaneus, that occurred while playing soccer. One week after presenting to the clinic, the patient underwent open Achilles tendon repair with augmentation fusing both regenerative tissue matrix and allogenic decellularized particular human placental connective tissue matrix. The patient’s pain (0-10), edema, and erythema were all recorded post-operatively on days 3, 10, 17, 24, and 38 in an outpatient clinical setting. Additionally, post-operatively, the patient was on opioid therapy for a short period of time. Significant improvement was noted in all three categories on post-operative day 17. Such findings indicate that the method of combining acellular dermal matrix and decellularized particulate human placental during an open Achilles tendon repair can possibly accelerate the post-operative course by leading to a quicker participation in physical therapy; consequently, leading to rapid return to daily activity and consuming less opioid pain medication post-operatively.